News & Announcements

  • PSROC Fellow award Prof. Fu-Jen Kao was awarded the prestigious PSROC Fellow award for his developments and applications of advanced optical microscopy in biomedical researches, as well as leading the internationalization initiative ...
    Posted Jun 13, 2017, 9:13 PM by MOL YMU
  • Prof. Fu-Jen Kao has been elected as the Vice President of AAPPS Prof Fu-Jen Kao has been elected as the Vice President of Association of Asia Pacific Physical Societies (AAPPS) for the duration (2017-2019) (link). The principal aim of AAPPS ...
    Posted Jun 13, 2017, 8:27 PM by MOL YMU
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Highlights

  • Advanced Optical Methods for Brain Imaging This book highlights the rapidly developing field of advanced optical methods for structural and functional brain imaging. As is known, the brain is the most poorly understood organ of a ...
    Posted Sep 25, 2018, 9:30 PM by Subir Das
  • Invited Review manuscript in METHODS is now online The invited review manuscript entitled “Polarization Resolved Second Harmonic Microscopy” has been accepted in the Elsevier journal ‘Methods’ and is now published online. In this invited review manuscript, the working ...
    Posted Jun 18, 2017, 9:15 PM by Ankur Gogoi
  • Latest Stokes vector resolved microscopy paper appears in Scientific Reports Recently our research paper entitled “Investigating starch gelatinization through Stokes vector resolved second harmonic generation microscopy” was published online in Scientific Reports. In this paper we reported the findings of ...
    Posted Jun 13, 2017, 9:04 PM by MOL YMU
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About us

The research in the Modern Optics Laboratory (MoL) focuses on developing novel techniques for super-resolution optical microscopy. The group has been able to develop a wonderful system of polarization resolved-SHG coupled with fluorescence life time imaging (FLIM). The laboratory is supervised by Prof. Fu-Jen Kao, who has been developing femto-second laser based multiphoton microscopy over the last decade and a half. Prof. Kao has established the first two-photon and second harmonic laser scanning microscope in Taiwan and also pioneered the combination of RF detection and femto-second laser to realized time-resolved optical beam induced current microscopy for a number of photonics devices. Additionally, Prof. Kao has initiated the use of optical parametric oscillator for harmonic generation microscopy. Recently, the MoL group has developed the first two-photon fluorescence lifetime imaging microscopy (FLIM) in Taiwan and has helped many groups in Taiwan and Canada in successfully installing FLIM on a conventional confocal microscope. The most recent achievements of the group include long working distance FLIM through stimulated emission and Stokes formalism based multiphoton polarization microscopy. One of the notable FLIM applications conducted by this group is the evaluation of intracellular metabolism by imaging metabolic status of NADH molecules within cells through two-photon FLIM. The group also designed a four-channel Stokes vector based SHG microscopy and demonstrated its potential to measure the complete polarization state of light. The Stokes vector based SHG microscopy was applied to investigate the structural properties of several second harmonic active molecules such as KDP, collagen fiber, starch granules etc.